IGF-1LR3
IGF-1 LR3 (Research Grade)
Product Overview:
IGF-1 LR3 (Long Arginine 3-Insulin-like Growth Factor-I) is a synthetic, recombinant analogue of endogenous human IGF-1. This specific variant features an amino acid substitution of Arginine for Glutamic Acid at position 3, as well as a 13-amino acid extension at the N-terminus. These modifications are designed for laboratory research to investigate the dynamics of protein-binding affinity and extended cellular signaling.
Key Technical Specifications:
Sequence: 83 Amino Acid Recombinant Analogue
Molecular Weight: 9111.6 Da
Purity: ≥99% (HPLC Verified)
Format: Lyophilized Powder
Storage: Store at -20°C for long-term stability; avoid repeated freeze-thaw cycles.
Primary Research Applications:
In controlled laboratory settings, IGF-1 LR3 is utilized to explore:
Binding Protein Interaction: Investigating how the "LR3" modification reduces the peptide's affinity for IGF-binding proteins (IGFBPs), allowing for the study of increased free-peptide concentrations.
Signal Transduction: Researching the activation of the AKT signaling pathway and its influence on cellular proliferation in vitro.
Metabolic Flux: Observing the effects of IGF-1 analogues on glucose uptake and amino acid transport in isolated cell cultures.
Myoblast Differentiation: Studying the molecular triggers involved in the transition of satellite cells in avian or murine models.
Handling & Storage:
Store in a controlled, low-temperature environment
Avoid repeated exposure to heat, moisture, and light
Handle using appropriate laboratory procedures
Compliance & Safety Disclaimer:
This product is supplied in accordance with industry-standard research material practices.
By purchasing, the customer confirms that:
They are acquiring this material for legitimate laboratory use only
They understand the product is not approved for human or veterinary use
They will handle and use the material in compliance with applicable regulations
For laboratory research use only. Not for human or veterinary use.