LL-37
LL-37 (Research Grade)
Product Overview:
LL-37 is a synthetic 37-amino acid peptide representing the only member of the cathelicidin family found in human physiological models. In laboratory settings, LL-37 is utilized to study the complex interactions between antimicrobial peptides (AMPs) and cellular membranes. It is a critical tool for researchers investigating the dynamics of innate molecular defense mechanisms and chemotactic signaling.
Key Technical Specifications:
Sequence: Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser
Molecular Formula: C205 H340 N60 O53
Purity: ≥99% (HPLC Verified)
Format: Lyophilized Powder
Storage: Store at -20°C for long-term stability; protect from light and moisture.
Primary Research Applications:
LL-37 is intended strictly for in vitro and animal research models to explore:
Membrane Interaction Dynamics: Investigating the "pore-forming" mechanisms and how amphipathic peptides interact with lipid bilayers.
Chemotactic Signaling: Studying the recruitment of leukocytes and other cellular components through the activation of formyl peptide receptors (FPRL1).
Biofilm Modulation: Researching the interaction between synthetic peptides and the structural integrity of microbial biofilms in laboratory cultures.
Signal Transduction: Observing the peptide's influence on the expression of various signaling molecules and its role in cellular homeostasis.
Handling & Storage:
Store in a controlled, low-temperature environment
Avoid repeated exposure to heat, moisture, and light
Handle using appropriate laboratory procedures
Compliance & Safety Disclaimer:
This product is supplied in accordance with industry-standard research material practices.
By purchasing, the customer confirms that:
They are acquiring this material for legitimate laboratory use only
They understand the product is not approved for human or veterinary use
They will handle and use the material in compliance with applicable regulations
For laboratory research use only. Not for human or veterinary use.